The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab116403 was purified by proprietary chromatographic techniques and filter sterilized.
Additional notesAlthough stable at 4°C for 1 week, ab116403 should be stored desiccated below -18°C. Please prevent freeze thaw cycles.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Please see notes section.
pH: 8.00 Constituents: 10% Glycerol, 0.32% Tris HCl
Arginase II mitochondrial
Arginase type II
Kidney type arginase
L arginine amidinohydrolase
L arginine ureahydrolase
Non hepatic arginase
Type II arginase
FunctionMay play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
Tissue specificityExpressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.
PathwayNitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Sequence similaritiesBelongs to the arginase family.