Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMSLRGSLSRLLQTRVHSILKKSVHSVAVIG APFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDD LYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGH ARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKV MERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIA EEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGG HIVYDQLPTPSSPDESENQARVRI
    • Molecular weight
      41 kDa including tags
    • Amino acids
      23 to 354
    • Tags
      His tag N-Terminus
    • Additional sequence information
      Mature.

Specifications

Our Abpromise guarantee covers the use of ab172173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    1.000 Eu/µg
  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8
    Constituents: 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • ARG2
    • ARGI2_HUMAN
    • Arginase II mitochondrial
    • Arginase type II
    • Arginase-2
    • arginase-2, mitochondrial
    • Kidney arginase
    • Kidney type arginase
    • Kidney-type arginase
    • L arginine amidinohydrolase
    • L arginine ureahydrolase
    • mitochondrial
    • Non hepatic arginase
    • Non-hepatic arginase
    • Nonhepatic arginase
    • Type II arginase
    see all
  • Function
    May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
  • Tissue specificity
    Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.
  • Pathway
    Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
  • Sequence similarities
    Belongs to the arginase family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab172173.

    Lane 1: Non-reduced

    Lane 2: Reduced

References

ab172173 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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