Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQG ADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKVSHSVAKLILVNFHW QVSEILDRYKSNSAQLLVEARVQPNPSKHVPTSHPPHHCAVCMQFVRKEN LLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPL LPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCN RCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKC NICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIV NQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNN LGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQL EAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT
    • Amino acids
      1 to 493
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • HT005
    • all trans retinoic acid inducible RING finger
    • Ari 2
    • Ari-2
    • ARI2
    • ARI2_HUMAN
    • Ariadne 2
    • Ariadne 2 protein homolog
    • ariadne homolog 2
    • ariadne homolog 2 (Drosophila)
    • Ariadne RBR E3 ubiquitin protein ligase 2
    • ARIH 2
    • Arih2
    • E3 ubiquitin protein ligase ARIH2
    • E3 ubiquitin-protein ligase ARIH2
    • protein ariadne 2 homolog
    • Protein ariadne-2 homolog
    • Triad 1
    • TRIAD1
    • Triad1 protein
    • UIP48
    see all
  • Function
    E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
  • Tissue specificity
    Widely expressed with higher expression in granulocytes.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the RBR family. Ariadne subfamily.
    Contains 1 IBR-type zinc finger.
    Contains 2 RING-type zinc fingers.
  • Domain
    RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis.
  • Post-translational
    modifications
    Ubiquitinated. Ubiquitination promotes proteasomal degradation.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus. Cytoplasm.
  • Information by UniProt

Images

  • ab160984 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160984 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab160984.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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