This product is an active protein and may elicit a biological response in vivo, handle with caution.
AMP activated protein kinase family member 5
AMPK related protein kinase 5
AMPK-related protein kinase 5
NUAK family SNF1 like kinase
NUAK family SNF1-like kinase 1
Omphalocele kinase 1
Probable serine/threonine protein kinase KIAA0537
FunctionInvolved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
Tissue specificityExpressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver.
Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Contains 1 protein kinase domain.
Post-translational modificationsUbiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.