Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAKV QVNNVVVLDN PSPFYNPFQF EITFECIEDL SEDLEWKIIY VGSAESEEYD QVLDSVLVGP VPAGRHMFVF QADAPNPGLI PDADAVGVTV VLITCTYRGQ EFIRVGYYVN NEYTETELRE NPPVKPDFSK LQRNILASNP RVTRFHINWE DNTEKLEDAE SSNPNLQSLL STDALPSASK GWSTSENSLN VMLESHMDCM

Specifications

Our Abpromise guarantee covers the use of ab84211 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab84211 is purified using conventional chromatography techniques.
  • FormLiquid
  • Additional notesEndotoxin Level: < 1.0 EU per 1 µg of protein (determined by LAL method).
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • Anti silencing function 1A
    • Anti-silencing function protein 1 homolog A
    • ASF1 anti silencing function 1 homolog A
    • ASF1 anti silencing function 1 homolog A (S. cerevisiae)
    • asf1a
    • ASF1A_HUMAN
    • CCG1 interacting factor A
    • CCG1-interacting factor A
    • CGI 98
    • CIA
    • hAsf1
    • hAsf1a
    • hCIA
    • Histone chaperone ASF1A
    • HSPC146
    see all
  • FunctionHistone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesBelongs to the ASF1 family.
  • Post-translational
    modifications
    Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase.
  • Cellular localizationNucleus.
  • Information by UniProt

Recombinant Human ASF1A protein images

  • 15% SDS-PAGE showing ab84211 at approximately 27kDa (3µg).

References for Recombinant Human ASF1A protein (ab84211)

ab84211 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab84211.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"