ASF1 anti silencing function 1 homolog A (S. cerevisiae)
CCG1 interacting factor A
CCG1-interacting factor A
Histone chaperone ASF1A
FunctionHistone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Tissue specificityUbiquitously expressed.
Sequence similaritiesBelongs to the ASF1 family.
Post-translational modificationsPhosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase.