Overview

  • Product name
    Recombinant Human ASIC3 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      25 kDa
    • Amino acids
      83 to 301

Specifications

Our Abpromise guarantee covers the use of ab126012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names
    • ACCN 3
    • Accn3
    • ACCN3_HUMAN
    • Acid sensing ion channel 3
    • Acid-sensing ion channel 3
    • Amiloride sensitive cation channel 3
    • Amiloride sensitive cation channel 3 testis
    • Amiloride-sensitive cation channel 3
    • ASIC 3
    • ASIC3
    • DRASIC
    • hASIC 3
    • hASIC3
    • hTNaC 1
    • hTNaC1
    • Modulatory subunit of ASIC 2a
    • Modulatory subunit of ASIC2a
    • Neuronal amiloride sensitive cation channel 3
    • Neuronal amiloride-sensitive cation channel 3
    • Proton gated cation channel subunit
    • SLNAC 1
    • SLNAC1
    • Testis sodium channel 1
    • TNaC 1
    • TNaC1
    see all
  • Function
    Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
  • Tissue specificity
    Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.
  • Sequence similarities
    Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN3 subfamily.
  • Developmental stage
    Expressed in fetal tissues, expression increases in lung and kidney adult tissues.
  • Domain
    The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1.
  • Post-translational
    modifications
    Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ACCN3/ASIC3-ACCN1/ASIC2b channel, but does not activate a homomeric ACCN3 channel.
  • Cellular localization
    Cell membrane. Cytoplasm. Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells.
  • Information by UniProt

References

ab126012 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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