This product is an active protein and may elicit a biological response in vivo, handle with caution.
Apoptosis signal regulating kinase 1
Apoptosis signal-regulating kinase 1
MAP/ERK kinase kinase 5
MAPK/ERK kinase kinase 5
MEK kinase 5
Mitogen activated protein kinase kinase kinase 5
Mitogen-activated protein kinase kinase kinase 5
FunctionComponent of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
Tissue specificityAbundantly expressed in heart and pancreas.
Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain.
Post-translational modificationsDephosphorylated and activated by PGAM5.