Overview

  • Product nameRecombinant Human ASPA protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP45381
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MGSMTSCHIAEEH IQKVAIFGGT HGNELTGVFL VKHWLENGAE IQRTGLEVKP FITNPRAVKK CTRYIDCDLN RIFDLENLGK KMSEDLPYEV RRAQEINHLF GPKDSEDSYD IIFDLHNTTS NMGCTLILED SRNNFLIQMF HYIKTSLAPL PCYVYLIEHP SLKYATTRSI AKYPVGIEVG PQPQGVLRAD ILDQMRKMIK HALDFIHHFN EGKEFPPCAI EVYKIIEKVD YPRDENGEIA AIIHPNLQDQ DWKPLHPGDP MFLTLDGKTI PLGGDCTVYP VFVNEAAYYE KKEAFAKTTK LTLNAKSIRC CLH
    • Molecular weight38 kDa including tags
    • Amino acids1 to 313
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123155 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity> 90 % SDS-PAGE.
    ab123155 was purified by using conventional chromatography.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.002% PMSF, 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • ACY 2
    • ACY-2
    • ACY2
    • ACY2_HUMAN
    • Aminoacylase 2
    • Aminoacylase-2
    • Aminoacylase2
    • ASP
    • ASPA
    • Aspartoacylase
    • Aspartoacylase (aminoacylase 2, Canavan disease)
    • Aspartoacylase (Canavan disease)
    • NUR 7
    • NUR7
    • OTTMUSP00000006437
    • RP23-213I10.1
    • Small lethargic
    see all
  • FunctionCatalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
  • Tissue specificityBrain white matter, skeletal muscle, kidney, adrenal glands, lung and liver.
  • Involvement in diseaseDefects in ASPA are the cause of Canavan disease (CAND) [MIM:271900]; also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average.
  • Sequence similaritiesBelongs to the AspA/AstE family. Aspartoacylase subfamily.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human ASPA protein images

  • 15% SDS-PAGE analysis of ab123155 (3 µg).

References for Recombinant Human ASPA protein (ab123155)

ab123155 has not yet been referenced specifically in any publications.

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