Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab51448 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

General Info

  • Alternative names
    • Activating transcription factor 1
    • ATF 1
    • atf1
    • ATF1 EWS fusion gene
    • ATF1 FUS fusion gene
    • ATF1_HUMAN
    • cAMP dependent transcription factor 1
    • cAMP-dependent transcription factor ATF-1
    • Cyclic AMP dependent transcription factor ATF 1
    • Cyclic AMP dependent transcription factor ATF1
    • Cyclic AMP-dependent transcription factor ATF-1
    • EWS AFT1
    • FUS ATF 1
    • FUS/ATF 1
    • Protein TREB36
    • RNA binding protein activating transcription factor 1 fusion protein
    • TREB 36
    • TREB36
    • TREB36 protein
    see all
  • Function
    This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes.
  • Involvement in disease
    Defects in ATF1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.
  • Sequence similarities
    Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
    Contains 1 KID (kinase-inducible) domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • Recombinant human ATF1 protein (tagged). Molecular weight 63 kDa.

References

ab51448 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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