The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
pH: 8.00 Constituents: 20% Glycerol, 0.32% Tris HCl, 12% Urea
Activating transcription factor 3
cAMP dependent transcription factor ATF3
cAMP-dependent transcription factor ATF-3
Cyclic AMP dependent transcription factor ATF3
Cyclic AMP-dependent transcription factor ATF-3
FunctionThis protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Sequence similaritiesBelongs to the bZIP family. ATF subfamily. Contains 1 bZIP domain.