Recombinant Human ATF6 beta protein (ab114637)

Overview

  • Product name
    Recombinant Human ATF6 beta protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      AELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRC PEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQVK
    • Molecular weight
      35 kDa including tags
    • Amino acids
      2 to 88

Specifications

Our Abpromise guarantee covers the use of ab114637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Activating transcription factor 6 beta
    • ATF 6 beta
    • ATF6-beta
    • ATF6B
    • ATF6B_HUMAN
    • ATF6beta
    • cAMP response element binding protein related protein
    • cAMP response element-binding protein-related protein
    • cAMP responsive element binding protein like 1
    • cAMP-dependent transcription factor ATF-6 beta
    • cAMP-responsive element-binding protein-like 1
    • CREB L1
    • Creb related protein
    • CREB RP
    • Creb-rp
    • CREBL 1
    • CREBL1
    • Crebrp
    • Cyclic AMP dependent transcription factor ATF 6 beta
    • Cyclic AMP dependent transcription factor ATF6 beta
    • FLJ10066
    • G13
    • G13 protein
    • OTTHUMP00000029432
    • OTTHUMP00000029433
    • Processed cyclic AMP-dependent transcription factor ATF-6 beta
    • Protein G13
    see all
  • Function
    Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • Domain
    The basic domain functions as a nuclear localization signal.
    The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
  • Post-translational
    modifications
    N-glycosylated.
    During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.
  • Cellular localization
    Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt

Recombinant Human ATF6 beta protein images

  • 12.5% SDS-PAGE image showing ab114637 Stained with Coomassie Blue.

References for Recombinant Human ATF6 beta protein (ab114637)

ab114637 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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