Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MEATGTDEVD KLKTKFISAW NNMKYSWVLK TKTYFSRNSP VLLLGKCYHF KYEDEDKTLP AESGCTIEDH VIAGNVEEFR KDFISRIWLT YREEFPQIEG SALTTDCGWG CTLRTGQMLL AQGLILHFLG RAWTWPDALN IENSDSESWT SHTVKKFTAS FEASLSGERE FKTPTISLKE TIGKYSDDHE MRNEVYHRKI ISWFGDSPLA LFGLHQLIEY GKKSGKKAGD WYGPAVVAHI LRKAVEEARH PDLQGITIYV AQDCTVYNSD VIDKQSASMT SDNADDKAVI ILVPVRLGGE RTNTDYLEFV KGILSLEYCV GIIGGKPKQS YYFAGFQDDS LIYMDPHYCQ SFVDVSIKDF PLETFHCPSP KKMSFRKMDP SCTIGFYCRN VQDFKRASEE ITKMLKFSSK EKYPLFTFVN GHSRDYDFTS TTTNEEDLFS EDEKKQLKRF STEEFVLL
    • Molecular weight
      53 kDa
    • Amino acids
      1 to 458
    • Tags
      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab152007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • APG4 autophagy 4 homolog C
    • APG4 autophagy 4 homolog C (S. cerevisiae)
    • APG4 C
    • APG4-C
    • APG4C
    • ATG 4C
    • ATG4 autophagy related 4 homolog C
    • ATG4 autophagy related 4 homolog C (S. cerevisiae)
    • Atg4c
    • ATG4C_HUMAN
    • AUT (S. cerevisiae) like 1, cysteine endopeptidase
    • AUT like 1, cysteine endopeptidase
    • AUT like 1, cysteine endopeptidase (S. cerevisiae)
    • AUT like 3 cysteine endopeptidase
    • AUT-like 3 cysteine endopeptidase
    • AUTL1
    • AUTL3
    • Autophagin 3
    • Autophagin-3
    • Autophagy related 4C cysteine peptidase
    • Autophagy related cysteine endopeptidase 3
    • Autophagy related protein 4 homolog C
    • Autophagy-related cysteine endopeptidase 3
    • Autophagy-related protein 4 homolog C
    • Cysteine protease ATG4C
    • EC 3.4.22
    • FLJ14867
    • OTTHUMP00000010715
    see all
  • Function
    Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
  • Tissue specificity
    Highly expressed in skeletal muscle, heart, liver and testis.
  • Sequence similarities
    Belongs to the peptidase C54 family.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

ab152007 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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