Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      23 kDa including tags
    • Amino acids
      134 to 285
    • Tags
      DDDDK tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab109136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Binds to Human and Mouse BAFFR, TACI and BCMA. Relative binding affinity (EC50) for BAFFR (Human): ~3ng/ml.
  • Applications

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 95 % SDS-PAGE.

  • Form
    Lyophilised
  • Additional notes
    After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.

    Preservative: None
    Constituents: PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute with 100µl sterile water to give a final concentration of 0.1mg/ml.

General Info

  • Alternative names
    • ApoL related ligand TALL 1
    • B cell Activating Factor
    • B lymphocyte stimulator
    • B-cell-activating factor
    • BAFF
    • BLyS
    • CD 257
    • CD257
    • CD257 antigen
    • Delta BAFF
    • Dendritic cell derived TNF like molecule
    • Dendritic cell-derived TNF-like molecule
    • DTL
    • DTL precursor
    • PRO738
    • soluble form
    • TALL 1
    • TALL-1
    • TALL1
    • THANK
    • TN13B_HUMAN
    • TNF and APOL related leukocyte expressed ligand 1
    • TNF homolog that activates apoptosis
    • TNF homolog that activates apoptosis NKFB and JNK.
    • TNF- and APOL-related leukocyte expressed ligand 1
    • TNFSF13B
    • TNFSF20
    • TNLG7A
    • Tumor necrosis factor (ligand) superfamily member 13b
    • Tumor necrosis factor ligand 7A
    • Tumor necrosis factor ligand superfamily member 13b
    • Tumor necrosis factor ligand superfamily member 20
    • Tumor necrosis factor like protein ZTNF4
    • Tumor necrosis factor superfamily member 13B
    • UNQ401
    • ZTNF4
    see all
  • Function
    Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
  • Tissue specificity
    Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas.
  • Sequence similarities
    Belongs to the tumor necrosis factor family.
  • Post-translational
    modifications
    The soluble form derives from the membrane form by proteolytic processing.
    N-glycosylated.
  • Cellular localization
    Secreted and Cell membrane.
  • Information by UniProt

References

ab109136 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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