The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityBiological activity determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5 - 2 µg/ml.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute to 1mg/ml with distilled water.
ApoL related ligand TALL 1
B cell Activating Factor
B lymphocyte stimulator
Dendritic cell derived TNF like molecule
Dendritic cell-derived TNF-like molecule
TNF and APOL related leukocyte expressed ligand 1
TNF homolog that activates apoptosis
TNF homolog that activates apoptosis NKFB and JNK.
TNF- and APOL-related leukocyte expressed ligand 1
Tumor necrosis factor (ligand) superfamily member 13b
Tumor necrosis factor ligand 7A
Tumor necrosis factor ligand superfamily member 13b
Tumor necrosis factor ligand superfamily member 20
Tumor necrosis factor like protein ZTNF4
Tumor necrosis factor superfamily member 13B
FunctionCytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Tissue specificityAbundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas.
Sequence similaritiesBelongs to the tumor necrosis factor family.
Post-translational modificationsThe soluble form derives from the membrane form by proteolytic processing. N-glycosylated.