Recombinant human BAFF Receptor protein (ab55757)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab55757 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityBlock BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 µg/ml in the presence of 1.0 µg/ml of human soluble BAFF.
  • Applications

    SDS-PAGE

    Functional Studies

  • Purity> 95 % SDS-PAGE.
    Purity: > 95% by SDS-PAGE and HPLC analyses. Endotoxin level < 0.1 ng per µg of BAFF-R
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Endotoxin level: < 0.1 ng per µg of soluble BAFF.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionReconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers.

General Info

  • Alternative names
    • B cell activating factor receptor
    • B-cell-activating factor receptor
    • BAFF R
    • BAFF receptor
    • BAFF-R
    • BAFFR
    • BLyS receptor 3
    • BlySR3
    • BR 3
    • BR3
    • BROMIX
    • CD 268
    • CD268
    • CD268 antigen
    • CVID4
    • MGC138235
    • OTTHUMP00000028746
    • Prolixin
    • TNFRSF 13C
    • Tnfrsf13c
    • TR13C_HUMAN
    • Tumor necrosis factor receptor subunit member 13C
    • Tumor necrosis factor receptor superfamily member 13C
    see all
  • FunctionB-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
  • Tissue specificityHighly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
  • Involvement in diseaseDefects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • Sequence similaritiesContains 1 TNFR-Cys repeat.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Recombinant human BAFF Receptor protein (ab55757)

ab55757 has not yet been referenced specifically in any publications.

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