Recombinant Human BAIAP2 protein (ab119452)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ9UQB8
    • SpeciesHuman
    • SequenceMSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTYAAK GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE LLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISN KQGELENYVS DGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPSKIPERA VQLMQQVASN GATLPSALSA SKSNLVISDP IPGAKPLPVP PELAPFVGRM SAQESTPIMN GVTGPDGEDY SPWADRKAAQ PKSLSPPQSQ SKLSDSYSNT LPVRKSVTPK NSYATTAENK TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG DLITLLVPEA RDGWHYGESE KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ GKSSSTGNLL DKDDLAIPPP DYGAASRAFP AQTASGFKQR PYSVAVPAFS QGLDDYGARS MSSGSGTLVS TVVEHHHHHH
    • Molecular weight58 kDa including tags
    • Amino acids1 to 522
    • TagsHis tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab119452 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab119452 was purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 30% Glycerol, 0.32% Tris HCl, 0.02% DTT, 0.58% Sodium chloride

General Info

  • Alternative names
    • BAI-associated protein 2
    • BAI1 associated protein 2
    • BAI1-associated protein 2
    • BAIAP 2
    • Baiap2
    • BAIP2_HUMAN
    • BAP2
    • Brain-specific angiogenesis inhibitor 1-associated protein 2
    • Fas ligand-associated factor 3
    • FLAF3
    • Insulin receptor substrate p53
    • Insulin receptor substrate p53/p58
    • Insulin receptor substrate protein of 53 kDa
    • IRS-58
    • IRSp53
    • IRSp53/58
    • Protein BAP2
    see all
  • FunctionAdapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation.
  • Tissue specificityIsoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
  • Sequence similaritiesContains 1 IMD (IRSp53/MIM homology) domain.
    Contains 1 SH3 domain.
  • DomainThe IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation.
    The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues by INSR in response to insulin treatment.
  • Cellular localizationCytoplasm. Membrane. Cell projection > filopodium. Cell projection > ruffle. Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles.
  • Information by UniProt

Recombinant Human BAIAP2 protein images

  • 15% SDS-PAGE showing ab119452 at approximately 58.4kDa (3µg).

References for Recombinant Human BAIAP2 protein (ab119452)

ab119452 has not yet been referenced specifically in any publications.

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