Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      36 kDa
    • Amino acids
      1 to 314
    • Tags
      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127216 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names
    • bccip
    • BCCIP_HUMAN
    • BCCIPalpha
    • BCCIPbeta
    • BRCA2 and CDKN1A interacting protein
    • BRCA2 and CDKN1A-interacting protein
    • BRCA2 and Cip1/p21 interacting protein
    • Cdk inhibitor p21 binding protein
    • P21 and CDK associated protein 1
    • P21- and CDK-associated protein 1
    • Protein TOK-1
    • Protein TOK1
    • TOK 1
    • TOK 1alpha
    • TOK 1beta
    • TOK1
    see all
  • Function
    May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
  • Tissue specificity
    Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
  • Sequence similarities
    Belongs to the BCP1 family.
  • Developmental stage
    Isoform 1 is expressed throughout the cell cycle. Isoform 2 is expressed following mitosis and peaks in the G1/S phase of the cell cycle.
  • Cellular localization
    Nucleus. Colocalizes with BRCA2 in discrete nuclear foci.
  • Information by UniProt

References

ab127216 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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