Recombinant Human BCCIP protein (BSA and azide free) (ab180349)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSEFMASRS KRRAVESGVP QPPDPPVQRD EEEEKEVENE DEDDDDSDKE KDEEDEVIDE EVNIEFEAYS LSDNDYDGIK KLLQQLFLKA PVNTAELTDL LIQQNHIGSV IKQTDVSEDS NDDMDEDEVF GFISLLNLTE RKGTQCVEQI QELVLRFCEK NCEKSMVEQL DKFLNDTTKP VGLLLSERFI NVPPQIALPM YQQLQKELAG AHRTNKPCGK CYFYLLISKT FVEAGKNNSK KKPSNKKKAA LMFANAEEEF FYEKAILKFN YSVQEESDTC LGGKWSFDDV PMTPLRTVML IPGDKMNEIM DKLKEYLSV
    • Molecular weight
      39 kDa including tags
    • Amino acids
      1 to 314
    • Tags
      His tag N-Terminus
    • Additional sequence information
      NP_510868

Specifications

Our Abpromise guarantee covers the use of ab180349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >90% by SDS-PAGE.
    ab180349 was purified using conventional chromatography.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.0
    Constituents: 0.32% Tris HCl, 0.88% Sodium chloride, 10% Glycerol, 0.02% DTT

General Info

  • Alternative names
    • bccip
    • BCCIP_HUMAN
    • BCCIPalpha
    • BCCIPbeta
    • BRCA2 and CDKN1A interacting protein
    • BRCA2 and CDKN1A-interacting protein
    • BRCA2 and Cip1/p21 interacting protein
    • Cdk inhibitor p21 binding protein
    • P21 and CDK associated protein 1
    • P21- and CDK-associated protein 1
    • Protein TOK-1
    • Protein TOK1
    • TOK 1
    • TOK 1alpha
    • TOK 1beta
    • TOK1
    see all
  • Function
    May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
  • Tissue specificity
    Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
  • Sequence similarities
    Belongs to the BCP1 family.
  • Developmental stage
    Isoform 1 is expressed throughout the cell cycle. Isoform 2 is expressed following mitosis and peaks in the G1/S phase of the cell cycle.
  • Cellular localization
    Nucleus. Colocalizes with BRCA2 in discrete nuclear foci.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab180349 (3 µg)

References

ab180349 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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