Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSHMEPTAP SLTEEDLTEV KKDALENLRV YLCEKIIAER HFDHLRAKKI LSREDTEEIS CRTSSRKRAG KLLDYLQENP KGLDTLVESI RREKTQNFLI QKITDEVLKL RNIKLEHLKG LKCSSCEPFP DGATNNLSRS NSDESNFSEK LRASTVMYHP EGESSTTPFF STNSSLNLPV LEVGRTENTI FSSTTLPRPG DPGAPPLPPD LQLEEEGTCA NSSEMFLPLR SRTVSRQ
    • Molecular weight
      29 kDa including tags
    • Amino acids
      1 to 233
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab124575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 85 % SDS-PAGE.
    ab124575 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names
    • AI132454
    • B cell CLL/lymphoma 10
    • B cell lymphoma/leukemia10
    • B-cell CLL/lymphoma 10
    • B-cell leukemia/lymphoma 10
    • B-cell lymphoma/leukemia 10
    • Bcl 10
    • Bcl-10
    • Bcl10
    • BCL10_HUMAN
    • c E10
    • c-E10
    • C81403
    • CARD containing apoptotic signaling protein
    • CARD containing molecule enhancing NF kappa B
    • CARD containing molecule enhancing NF kB
    • CARD containing molecule enhancing NF-kB
    • CARD containing molecule enhancing NFkB
    • CARD containing proapoptotic protein
    • CARD like apoptotic protein
    • CARD-containing apoptotic signaling protein
    • CARD-containing molecule enhancing NF-kappa-B
    • CARD-containing proapoptotic protein
    • CARD-like apoptotic protein
    • CARMEN
    • Caspase recruiting domain containing protein
    • caspase-recruiting domain-containing protein
    • cCARMEN
    • cE 10
    • cE10
    • CED 3/ICH 1 prodomain homologous E10 like regulator
    • CED-3/ICH-1 prodomain homologous E10-like regulator
    • CED3/ICH1 prodomain homologous E10 like regulator
    • Cellular E10
    • Cellular homolog of vCARMEN
    • Cellular-E10
    • CIPER
    • CLAP
    • hCLAP
    • Mammalian CARD containing adapter molecule E10
    • Mammalian CARD-containing adapter molecule E10
    • mE 10
    • mE10
    • R-RCD1
    see all
  • Function
    Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
    Note=Defects in BCL10 are involved in various types of cancer.
  • Sequence similarities
    Contains 1 CARD domain.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2.
  • Cellular localization
    Cytoplasm > perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab124575 at approximately 28.8kDa (3µg).
    Note: (Molecular weight on SDS-PAGE will appear higher).

References

ab124575 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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