Overview

  • Product name
    Recombinant Human Bcl6 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      1 to 150

Specifications

Our Abpromise guarantee covers the use of ab39476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

General Info

  • Alternative names
    • B cell CLL/lymphoma 6
    • B cell lymphoma 6 protein
    • B-cell lymphoma 5 protein
    • B-cell lymphoma 6 protein
    • BCL 5
    • Bcl 6
    • BCL-5
    • BCL-6
    • BCL5
    • BCL6
    • BCL6_HUMAN
    • BCL6A
    • cys his2 zinc finger transcription factor
    • LAZ 3
    • LAZ 3 protein
    • LAZ3
    • Lymphoma associated zinc finger gene on chromosome 3
    • Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3)
    • Protein LAZ-3
    • ZBTB 27
    • ZBTB27
    • Zinc finger and BTB domain containing protein 27
    • Zinc finger and BTB domain-containing protein 27
    • Zinc finger and BTB domain-containing protein 27 (ZBTB27)
    • Zinc finger protein 51
    • Zinc Finger Protein 51 (ZNF51)
    • zinc finger transcription factor BCL6S
    • ZNF 51
    • ZNF51
    see all
  • Function
    Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
  • Tissue specificity
    Expressed in germinal center T and B cells and in primary immature dendritic cells.
  • Involvement in disease
    Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.
    Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
    Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
  • Sequence similarities
    Contains 1 BTB (POZ) domain.
    Contains 6 C2H2-type zinc fingers.
  • Domain
    The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2.
  • Post-translational
    modifications
    Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab39476 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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