Lymphoma associated zinc finger gene on chromosome 3
Zinc finger and BTB domain containing protein 27
Zinc finger and BTB domain-containing protein 27
Zinc finger protein 51
zinc finger transcription factor BCL6S
FunctionTranscriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
Tissue specificityExpressed in germinal center T and B cells and in primary immature dendritic cells.
Involvement in diseaseNote=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.