Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      AGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNA
    • Molecular weight
      5 kDa
    • Amino acids
      5 to 54

Associated products

Specifications

Our Abpromise guarantee covers the use of ab111458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Purity
    >= 98 % SDS-PAGE.
    ab111458 is purified by standard chromatographic techniques. Purity is greater than 98% by HPLC and SDS-PAGE.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    pH: 7.40
    Constituents: 0.76% Sodium chloride, 0.28% Sodium phosphate

  • Reconstitution
    Reconstitute in sterile ddH2O to a concentration of 100 µg/ml. This solution can then be diluted into other aqueous buffers.

General Info

  • Alternative names
    • B cell maturation antigen
    • B cell maturation factor
    • B cell maturation protein
    • B-cell maturation protein
    • BCM
    • BCMA
    • CD269
    • CD269 antigen
    • TNFRSF17
    • TNR17_HUMAN
    • Tumor necrosis factor receptor superfamily member 17
    see all
  • Function
    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
  • Tissue specificity
    Expressed in mature B-cells, but not in T-cells or monocytes.
  • Involvement in disease
    Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
  • Sequence similarities
    Contains 1 TNFR-Cys repeat.
  • Cellular localization
    Cell membrane. Endomembrane system. Perinuclear Golgi-like structures.
  • Information by UniProt

References

ab111458 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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