Recombinant Human BCMA protein (ab50089)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceAGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA
    • Amino acids5 to 54

Associated products

Specifications

Our Abpromise guarantee covers the use of ab50089 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level< 0.100 Eu/µg
  • Purity> 95 % SDS-PAGE.
    ab50089 purity was evaluated also by HPLC. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

  • ReconstitutionReconstitute to 1mg/ml with distilled water.

General Info

  • Alternative names
    • B cell maturation antigen
    • B cell maturation factor
    • B cell maturation protein
    • B-cell maturation protein
    • BCM
    • BCMA
    • CD269
    • CD269 antigen
    • TNFRSF17
    • TNR17_HUMAN
    • Tumor necrosis factor receptor superfamily member 17
    see all
  • FunctionReceptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
  • Tissue specificityExpressed in mature B-cells, but not in T-cells or monocytes.
  • Involvement in diseaseNote=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
  • Sequence similaritiesContains 1 TNFR-Cys repeat.
  • Cellular localizationCell membrane. Endomembrane system. Perinuclear Golgi-like structures.
  • Information by UniProt

References for Recombinant Human BCMA protein (ab50089)

ab50089 has not yet been referenced specifically in any publications.

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Abreviews
Application ELISA
ab50089 was coated overnight at 4 degrees C at a concentration of 2 ug/mL. The goat anti-human BCMA antibody AF193 was used at a concentration of 1 ug/mL and incubated for 1 hour at room temperature to detect ab50089. 1% milk in TBST was used as the blocking agent and diluent. Excellent signal over background was observed. The average of eight replicates is shown with standard deviation included by error bars.
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Submitted Feb 22 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"