The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Basic helix loop helix domain containing class B 8
Basic helix loop helix family member a15
Class A basic helix-loop-helix protein 15
Class B basic helix-loop-helix protein 8
Class II bHLH protein MIST1
intestine and stomach expression 1
Muscle intestine and stomach expression 1
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.
Expressed in brain, liver, spleen and skeletal muscle.
Contains 1 basic helix-loop-helix (bHLH) domain.
Lacks a classic transcription activation domain and instead possesses an N-terminal region capable of inhibiting heterologous activators.