Recombinant Human Bile Acid Receptor NR1H4 protein (ab81918)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab81918 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity1 unit equals 1 nanogram purified protein.
  • Applications

    SDS-PAGE

    EMSA

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Additional notes1 unit equals 1 nanogram purified protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

General Info

  • Alternative names
    • BAR
    • Bile acid receptor
    • Farnesoid X activated receptor
    • Farnesoid X receptor
    • Farnesoid X-activated receptor
    • Farnesol receptor HRR 1
    • Farnesol receptor HRR-1
    • Farnesol receptor HRR1
    • FXR
    • HRR 1
    • HRR1
    • NR1H4
    • NR1H4_HUMAN
    • Nuclear receptor subfamily 1 group H member 4
    • Retinoid X receptor interacting protein 14
    • Retinoid X receptor-interacting protein 14
    • RIP 14
    • RIP14
    • RXR interacting protein 14
    • RXR-interacting protein 14
    see all
  • FunctionLigand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Recombinant Human Bile Acid Receptor NR1H4 protein (ab81918)

ab81918 has not yet been referenced specifically in any publications.

Product Wall

Merci pour la confirmation.

Comme convenu j'ai demandé à notre service comptabilité de mettre en place un avoir référence CN.

Votre référence CN est ******.

Voici les man...

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Merci pour votre réponse.

Je comprends vos interrogations concernantla qualité dece produit et je serais absolument d'accord pour éditer un remboursement.

Cependant, sachez que si le nouveau lot que je vous prop...

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Merci pour votre patience.

Le laboratoire qui produit la protéine ab81918'Bile Acid Receptor NR1H4 protein (His tag)' vient de m'informer et confirmer que le nouveau lot correspond bienà la protéine humaine (U68233) : Read More

Merci de nous avoir contactés et désolé pour le délai de ma réponse, j'attendais une réponse du laboratoire.

J'ai été informé que des tests de caractérisation vont êt...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"