Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MQWIEPRNCA RRYLKVDFAD IGWSEWIISP KSFDAYYCSG ACQFPMPKSL KPSNHATIQS IVRAVGVVPG IPEPCCVPEK MSSLSILFFD ENKNVVLKVY PNMTVESCAC R
    • Molecular weight
      13 kDa
    • Amino acids
      363 to 472

Specifications

Our Abpromise guarantee covers the use of ab97412 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 95 % SDS-PAGE.
    Purity is greater than 95% by SDS-PAGE gel and HPLC analyses.
  • Form
    Lyophilised
  • Additional notes
    Determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells. Determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    The lyophilized protein is stable at room temperature for up to 1 month. Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C.

General Info

  • Alternative names
    • BMP-3
    • BMP-3A
    • bmp3
    • BMP3_HUMAN
    • BMP3A
    • Bone morphogenetic protein 3
    • Bone morphogenetic protein 3 (osteogenic)
    • Bone morphogenetic protein 3A
    • Osteogenin
    see all
  • Function
    Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
  • Tissue specificity
    Expressed in adult and fetal cartilage.
  • Sequence similarities
    Belongs to the TGF-beta family.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab97412 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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