The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityDetermined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. Purity is greater than 95% by SDS-PAGE gel and HPLC analyses.
Additional notesDetermined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
Determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionThe lyophilized protein is stable at room temperature for up to 1 month. Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C.
Bone morphogenetic protein 3
Bone morphogenetic protein 3 (osteogenic)
Bone morphogenetic protein 3A
FunctionNegatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
Tissue specificityExpressed in adult and fetal cartilage.
Sequence similaritiesBelongs to the TGF-beta family.