FunctionInduces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Tissue specificityExpressed in the kidney and bladder. Lower levels seen in the brain.
Sequence similaritiesBelongs to the TGF-beta family.
Developmental stageExpressed in the developing eye, brain and ear during embryogenesis.
Post-translational modificationsSeveral N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).