This product is an active protein and may elicit a biological response in vivo, handle with caution.
Activin A receptor type II like kinase 3
Activin receptor like kinase 3
Activin receptor-like kinase 3
BMP type-1A receptor
Bone morphogenetic protein receptor type IA
Bone morphogenetic protein receptor type IA precursor
Bone morphogenetic protein receptor type-1A
Serine threonine protein kinase receptor R5
Serine threonine protein kinase receptor R5 precursor
Serine/threonine-protein kinase receptor R5
FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
Tissue specificityHighly expressed in skeletal muscle.
Involvement in diseaseJuvenile polyposis syndrome Polyposis syndrome, mixed hereditary 2 A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome.
Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.