The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab116488 was purified by proprietary chromatographic techniques and filter sterilized.
Additional notesalthough stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Please see notes section.
pH: 8.00 Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol
2,3-bisphosphoglycerate mutase, erythrocyte
BPG dependent PGAM
Erythrocyte 2,3 bisphosphoglycerate mutase
FunctionPlays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 220.127.116.11) and phosphatase (EC 18.104.22.168) activities.
Involvement in diseaseDefects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD) [MIM:222800]. A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis.
Sequence similaritiesBelongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Post-translational modificationsGlycation of Lys-159 in diabetic patients inactivates the enzyme.