FunctionSerine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
Tissue specificityExpressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle.
Sequence similaritiesBelongs to the AB hydrolase superfamily. Lipase family.