• NatureRecombinant
  • SourceBaculovirus
  • Amino Acid Sequence
    • SpeciesHuman
    • TagsHis tag N-Terminus


Our Abpromise guarantee covers the use of ab84143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity1 unit equals 1 nanogram of purified protein.
  • Applications


  • Purity> 90 % SDS-PAGE.
    ab84143 is purified by affinity and FPLC chromatography.
  • FormLiquid
  • Additional notes1 unit equals 1 nanogram of purified protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

General Info

  • Alternative names
    • Activator protein 1
    • AP 1
    • C FOS
    • Cellular oncogene c fos
    • Cellular oncogene fos
    • FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS)
    • FBJ murine osteosarcoma viral oncogene homolog
    • FBJ murine osteosarcoma viral v fos oncogene homolog
    • FBJ Osteosarcoma Virus
    • FOS
    • FOS protein
    • G0 G1 switch regulatory protein 7
    • G0/G1 switch regulatory protein 7
    • G0S7
    • Oncogene FOS
    • p55
    • proto oncogene c Fos
    • Proto oncogene protein c fos
    • Proto-oncogene c-Fos
    • v fos FBJ murine osteosarcoma viral oncogene homolog
    see all
  • FunctionNuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
  • Sequence similaritiesBelongs to the bZIP family. Fos subfamily.
    Contains 1 bZIP domain.
  • Post-translational
    Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation.
    Constitutively sumoylated by SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Recombinant Human c-Fos protein (ab84143)

ab84143 has not yet been referenced specifically in any publications.

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