Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMAGEEIN EDYPVEIHEY LSAFENSIGA VDEMLKTMMS VSRNELLQKL DPLEQAKVDL VSAYTLNSMF WVYLATQGVN PKEHPVKQEL ERIRVYMNRV KEITDKKKAG KLDRGAASRF VKNALWEPKS KNASKVANKG KSKS
    • Molecular weight
      18 kDa including tags
    • Amino acids
      1 to 141
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab156979 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 85 % SDS-PAGE.
    ab156979 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.03% DTT, 0.32% Tris HCl, 50% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names
    • 1110036E10Rik
    • AI875855
    • C1D
    • C1D DNA binding protein
    • C1D_HUMAN
    • hC1D
    • LRP1
    • MGC12261
    • MGC14659
    • MGC188504
    • Nuclear DNA binding protein
    • Nuclear nucleic acid binding protein C1D
    • Nuclear nucleic acid-binding protein C1D
    • rCG23324
    • RGD1560600
    • Small unique nuclear receptor corepressor
    • SUNCOR
    see all
  • Function
    Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB.
  • Tissue specificity
    Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland. Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon.
  • Sequence similarities
    Belongs to the C1D family.
  • Post-translational
    modifications
    Phosphorylated by PRKDC.
  • Cellular localization
    Cytoplasm. Nucleus > nucleolus. EXOSC10 is required for nucleolar localization.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab156979 (3µg).

References

ab156979 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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