Recombinant Human C20orf19 protein (ab163256)

Overview

  • Product name
    Recombinant Human C20orf19 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MQLEYETQIKKMLCSKDSLGLKEELTDEDREKVAVQEGINSGTAMSRGLY QPATIFMGRQMSAILSMRDFSTEHKSPQPTKNFSIPDPHSHRQTAQSSNV TDSCVVQTSNDTQCLNKSDNIDGKASLQIGEKTPVTASVLSEEEQTHCLE IGSNTRHGKSNLSEGKKSAELNSPLRERLSPENRTTDLKCDSSSGSEGEI LTREHIEVEEKRASPPVSPIPVSEYCESENKWSQEKHSPWEGVSDHLAHR EPKSQKPFRKMQEEEEESWSTSSDLTISISEDDLILESPEPQPNPGGKME GEDGIEALKLIHAEQERVALSTEKNCILQTLSSPDSEKESSTNAPTREPG QTPDSDVPRAQVGQHVATLKEHDNSVKEEATALLRKALTEECGRRSAIHS SESSCSLPSILNDNSGIKEAKPAVWLNSVPTREQEVSSGCGDKSKKENVA ADIPITETEAYQLLKKATLQDNTNQTENRFQKTDASVSHLSGLNIGSGAF ETKTANKIASEASFSSSEGSPLSRHENKKKPVINLKSNALWDESDDSNSE IEAALRPRNHNTDDSDDFYD
    • Amino acids
      1 to 570
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163256 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Centrosomal protein kizuna
    • DKFZP586H021
    • HT013
    • Kiz
    • KIZ_HUMAN
    • KIZUNA
    • MGC102941
    • MGC141930
    • NCRNA00153
    • Plk1s1
    • Polo-like kinase 1 substrate 1
    • Uncharacterized protein C20orf19
    see all
  • Function
    Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
  • Sequence similarities
    Belongs to the kizuna family.
  • Post-translational
    modifications
    Phosphorylation at Thr-379 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization.
  • Cellular localization
    Cytoplasm > cytoskeleton > centrosome. Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule-independent and dependent manner, respectively.
  • Information by UniProt

Images

  • ab163256 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163256 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab163256.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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