Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Associated products

Specifications

Our Abpromise guarantee covers the use of ab74979 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

General Info

  • Alternative names
    • C3IP1
    • CUL3 interacting protein 1
    • CUL3-interacting protein 1
    • DKIR
    • DKIR homolog
    • FLJ27152
    • hDKIR
    • Kelch like 12
    • Kelch like 12 (Drosophila)
    • Kelch like 12 variant
    • Kelch like protein 12
    • Kelch like protein C3IP1
    • kelch-like family member 12
    • Kelch-like protein 12
    • KLH12_HUMAN
    • KLHL 12
    • klhl12
    • OTTHUMP00000038799
    see all
  • FunctionServes as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.
  • Tissue specificityHighly expressed in testis and at lower levels in the submandibular salivary gland.
  • Sequence similaritiesContains 1 BTB (POZ) domain.
    Contains 6 Kelch repeats.
  • DomainThe BTB domain is required for interaction with CUL3.
  • Information by UniProt

Recombinant Human C3IP1 protein images

  • SDS-PAGE showing ab74979 at approximately 65kDa.

References for Recombinant Human C3IP1 protein (ab74979)

ab74979 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"