Recombinant Human C4 binding protein (ab114462)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MFFWCACCLMVAWRVSASDEHCPELPPVDNSIFVAKEVEGQILGTYVC IKGYHLVGKKTLFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNV SDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGY FEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVCKLIQEAPK PECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELKA KLL
    • Molecular weight
      53 kDa including tags
    • Amino acids
      1 to 252

Associated products

Specifications

Our Abpromise guarantee covers the use of ab114462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    ab114462 is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • C4b binding protein beta chain
    • C4b-binding protein beta chain
    • C4BP
    • C4BPB
    • C4BPB_HUMAN
    • Complement component 4 binding protein beta
    • Complement component 4 binding protein beta chain
    • Complement component 4-binding protein beta
    • OTTHUMP00000034288
    • OTTHUMP00000034289
    • OTTHUMP00000034375
    • OTTHUMP0000003474
    • Proline rich protein
    • PRP
    see all
  • Function
    Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
  • Sequence similarities
    Contains 3 Sushi (CCP/SCR) domains.
  • Cellular localization
    Secreted.
  • Information by UniProt

Images

  • ab114462 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab114462 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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