The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab99141 was purified by using conventional chromatography.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 10% Glycerol, 20mM Tris HCl, pH 7.5
Calcineurin B homolog
Calcineurin B homologous protein
Calcineurin homologous protein
Calcium binding protein CHP
Calcium binding protein p22
Calcium-binding protein CHP
Calcium-binding protein p22
SLC9A1 binding protein
FunctionRequired for constitutive membrane traffic. Inhibits GTPase-stimulated Na(+)/H(+) exchange. Also inhibits calcineurin phosphatase activity. Required for activity of SLC9A1/NHE1.
Tissue specificityUbiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen.
Sequence similaritiesContains 4 EF-hand domains.
Post-translational modificationsBoth N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic. Phosphorylated; decreased phosphorylation is associated with an increase in exchange activity. The phosphorylation state may regulate the binding to NHE1.