Patatin like phospholipase domain containing protein 9
Patatin-like phospholipase domain-containing protein 9
Phospholipase A2 calcium independent
Phospholipase A2 calcium independent group VI A
Phospholipase A2 group VI
Phospholipase A2 group VI cytosolic calcium independent
Phospholipase A2, group VI (cytosolic, calcium independent)
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
Four different transcripts were found to be expressed in a distinct tissue distribution.
Involvement in disease
Neurodegeneration with brain iron accumulation 2B Neurodegeneration with brain iron accumulation 2A Parkinson disease 14