Recombinant Human Calpain 3 protein (ab114576)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYE PHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSN KELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIA GDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKL NLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQL YDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVL EWLQLTMYA
    • Molecular weight
      60 kDa including tags
    • Amino acids
      1 to 309

Specifications

Our Abpromise guarantee covers the use of ab114576 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Calcium-activated neutral proteinase 3
    • calpain 3, (p94)
    • Calpain L3
    • Calpain large polypeptide L3
    • Calpain p94
    • calpain p94, large [catalytic] subunit
    • calpain, large polypeptide L3
    • Calpain-3
    • CAN3_HUMAN
    • CANP 3
    • CANP3
    • CANPL3
    • CAPN3
    • LGMD 2A
    • LGMD2
    • LGMD2A
    • Lp82
    • Lp85
    • MGC10767
    • MGC11121
    • MGC14344
    • MGC4403
    • Muscle-specific calcium-activated neutral protease 3
    • muscle-specific calcium-activated neutral protease 3 large subunit
    • nCL-1
    • New calpain 1
    • p94
    see all
  • Function
    Calcium-regulated non-lysosomal thiol-protease.
  • Tissue specificity
    Isoform I is skeletal muscle specific.
  • Involvement in disease
    Defects in CAPN3 are the cause of limb-girdle muscular dystrophy type 2A (LGMD2A) [MIM:253600]. LGMD2A is an autosomal recessive degenerative myopathy characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. The symptoms usually begin during the first two decades of life, and the disease gradually worsens, often resulting in loss of walking ability 10 or 20 years after onset.
  • Sequence similarities
    Belongs to the peptidase C2 family.
    Contains 1 calpain catalytic domain.
    Contains 4 EF-hand domains.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Recombinant Human Calpain 3 protein images

  • ab114576 on a 12.5% SDS-PAGE Stained with Coomassie Blue.

References for Recombinant Human Calpain 3 protein (ab114576)

ab114576 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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