Recombinant Human CaMKII beta protein (ab172820)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKL SARDHQKLEREARIC RLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASH CIQQILEAVLHCHQM GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY LSPEVLRKEAYGKPV DIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEA KNLINQMLTINPAKR ITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLA TRNFSAAKSLLNKKA DGVKPQTNSTKNSAAATSPKGTLPPAALESSDSANTTIEDEDAKARKQEI IKTTEQLIEAVNNGD FEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTIL NPHVHVIGEDAACIA YIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQLE HHHHHH
    • Molecular weight
      56 kDa
    • Amino acids
      1 to 503
    • Tags
      His tag C-Terminus
    • Additional sequence information
      Isoform 2.

Specifications

Our Abpromise guarantee covers the use of ab172820 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    SDS-PAGE

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    >95% by SDS-PAGE .
    Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.5
    Constituents: 0.24% HEPES, 0.88% Sodium chloride

    Supplied as a 0.2 µM filtered solution.

General Info

  • Alternative names
    • Calcium/calmodulin dependent protein kinase (CaM kinase) II beta
    • Calcium/calmodulin dependent protein kinase II beta
    • Calcium/calmodulin dependent protein kinase IIB
    • Calcium/calmodulin dependent protein kinase type II beta chain
    • calcium/calmodulin-dependent protein kinase II beta
    • Calcium/calmodulin-dependent protein kinase type II subunit beta
    • CAM 2
    • CaM kinase II beta chain
    • CaM kinase II beta subunit
    • CaM kinase II subunit beta
    • CaM-kinase II beta chain
    • CAM2
    • CAMK 2
    • CAMK 2B
    • CaMK II beta subunit
    • CaMK II subunit beta
    • CaMK-II subunit beta
    • CAMK2
    • CaMK2 beta
    • Camk2b
    • CAMKB
    • CaMKII beta subunit
    • CaMKIIB
    • KCC2B_HUMAN
    • MGC29528
    • Proline rich calmodulin dependent protein kinase
    • proline rich calmodulin-dependent protein kinase
    see all
  • Function
    CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
  • Tissue specificity
    Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 1 protein kinase domain.
  • Information by UniProt

References

ab172820 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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