Recombinant Human CAMKIV protein (ab119450)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMGSHMLKVTVPSCSASSCSSVTASAAPGTA SLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKV LKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGEL FDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPA PDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWS VGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDL VRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKL KAAVKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGE KIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAVEDGIK VADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
    • Molecular weight
      55 kDa including tags
    • Amino acids
      1 to 473
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab119450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 85 % SDS-PAGE.
    ab119450 was purified using conventional chromatography. Purity is > 85% by SDS-PAGE.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • Brain Ca(2+) calmodulin dependent protein kinase type 4
    • Brain Ca(2+) calmodulin dependent protein kinase type IV
    • Brain Ca++-calmodulin dependent protein kinase type IV
    • Calcium / calmodulin dependent protein kinase type 4 catalytic chain
    • Calcium / calmodulin dependent protein kinase type IV catalytic chain
    • Calcium/calmodulin dependent protein kinase IV
    • Calcium/calmodulin dependent protein kinase type IV
    • Calcium/calmodulin-dependent protein kinase type IV
    • CAM kinase 4
    • CAM kinase GR
    • CAM kinase IV
    • CAM kinase-GR
    • CaMK 4
    • CAMK GR
    • CaMK IV
    • Camk4
    • CaMKGR
    • IV
    • KCC4_HUMAN
    • MGC36771
    see all
  • Function
    Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory.
  • Tissue specificity
    Expressed in epithelial ovarian cancer tissue.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.
  • Cellular localization
    Cytoplasm. Nucleus. Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix.
  • Information by UniProt

Images

  • 12% SDS-PAGE showing ab119450 at approximately 54.5kDa (3µg).

References

ab119450 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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