Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab60756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • FormLiquid
  • Additional notes

    ab188554 (CaMKII peptide) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

General Info

  • Alternative names
    • Brain Ca(2+) calmodulin dependent protein kinase type 4
    • Brain Ca(2+) calmodulin dependent protein kinase type IV
    • Brain Ca++-calmodulin dependent protein kinase type IV
    • Calcium / calmodulin dependent protein kinase type 4 catalytic chain
    • Calcium / calmodulin dependent protein kinase type IV catalytic chain
    • Calcium/calmodulin dependent protein kinase IV
    • Calcium/calmodulin dependent protein kinase type IV
    • Calcium/calmodulin-dependent protein kinase type IV
    • CAM kinase 4
    • CAM kinase GR
    • CAM kinase IV
    • CAM kinase-GR
    • CaMK 4
    • CAMK GR
    • CaMK IV
    • Camk4
    • CaMKGR
    • IV
    • KCC4_HUMAN
    • MGC36771
    see all
  • FunctionCalcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory.
  • Tissue specificityExpressed in epithelial ovarian cancer tissue.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.
  • Cellular localizationCytoplasm. Nucleus. Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix.
  • Information by UniProt

Recombinant Human CAMKIV protein images

  • Sample Kinase Activity Plot.
  • ab60756 on SDS-PAGE, MW ~79kDa.

References for Recombinant Human CAMKIV protein (ab60756)

ab60756 has not yet been referenced specifically in any publications.

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