This product is an active protein and may elicit a biological response in vivo, handle with caution.
Ca2+/calmodulin-dependent protein kinase kinase alpha
Calcium/calmodulin dependent protein kinase kinase
Calcium/calmodulin dependent protein kinase kinase 1
Calcium/calmodulin dependent protein kinase kinase 1 alpha
Calcium/calmodulin dependent protein kinase kinase alpha
Calcium/calmodulin-dependent protein kinase kinase 1
Calcium/calmodulin-dependent protein kinase kinase alpha
CaM kinase kinase alpha
CaM-kinase IV kinase
CaM-kinase kinase 1
CaM-kinase kinase alpha
CAMKK alpha protein
FunctionCalcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
DomainThe autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
Post-translational modificationsAppears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4.