Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ8WVQ1
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MGSHMRPAPG RPPTHNAHNW RLGQAPANWY NDTYPLSPPQ RTPAGIRYRI AVIADLDTES RAQEENTWFS YLKKGYLTLS DSGDKVAVEW DKDHGVLESH LAEKGRGMEL SDLIVFNGKL YSVDDRTGVV YQIEGSKAVP WVILSDGDGT VEKGFKAEWL AVKDERLYVG GLGKEWTTTT GDVVNENPEW VKVVGYKGSV DHENWVSNYN ALRAAAGIQP PGYLIHESAC WSDTLQRWFF LPRRASQERY SEKDDERKGA NLLLSASPDF GDIAVSHVGA VVPTHGFSSF KFIPNTDDQI IVALKSEEDS GRVASYIMAF TLDGRFLLPE TKIGSVKYEG IEFI
    • Molecular weight41 kDa including tags
    • Amino acids63 to 401
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123189 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity> 90 % SDS-PAGE.
    ab123189 is purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names
    • Apyrase
    • Apyrase homolog
    • Ca2+ dependent endoplasmic reticulum nucleoside diphosphatase
    • Calcium activated nucleotidase 1
    • CANT 1
    • CANT1
    • CANT1_HUMAN
    • Putative MAPK activating protein PM09
    • Putative MAPK-activating protein PM09
    • Putative NF kappa B activating protein 107
    • Putative NF-kappa-B-activating protein 107
    • SCAN 1
    • SCAN-1
    • SHAPY
    • Soluble Ca activated nucleotidase isozyme 1
    • Soluble calcium activated nucleotidase 1
    • Soluble calcium activated nucleotidase SCAN 1
    • Soluble calcium-activated nucleotidase 1
    see all
  • FunctionCalcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP.
  • Tissue specificityWidely expressed.
  • Involvement in diseaseDefects in CANT1 are the cause of Desbuquois dysplasia (DBQD) [MIM:251450]. A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations.
  • Sequence similaritiesBelongs to the apyrase family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Processed form: Secreted.
  • Information by UniProt

Recombinant Human CANT1 protein images

  • 15% SDS-PAGE showing ab123189 (3µg).

References for Recombinant Human CANT1 protein (ab123189)

ab123189 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123189.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"