Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab38230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

General Info

  • Alternative names
    • Bcl10 interacting MAGUK protein 2
    • Bimp 2
    • Bimp2
    • CAR14_HUMAN
    • CARD 14
    • CARD containing MAGUK 2 protein
    • CARD containing MAGUK protein 2
    • Card maguk protein 2
    • CARD-containing MAGUK protein 2
    • CARD14
    • Carma 2
    • Carma2
    • Caspase recruitment domain containing protein 14
    • Caspase recruitment domain family member 14
    • Caspase recruitment domain protein 14
    • Caspase recruitment domain-containing protein 14
    • PRP
    • PSORS2
    • PSS1
    see all
  • FunctionActivates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
  • Tissue specificityExpressed in placenta. Also detected in HeLaS3 cell line, but not in the other cancer cell lines tested. Expressed in epidermal keratinocytes.
  • Involvement in diseaseDefects in CARD14 are the cause of susceptibility to psoriasis type 2 (PSORS2) [MIM:602723]. A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
    Defects in CARD14 are the cause of pityriasis rubra pilaris (PRP) [MIM:173200]. A rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.
  • Sequence similaritiesContains 1 CARD domain.
    Contains 1 guanylate kinase-like domain.
    Contains 1 PDZ (DHR) domain.
  • Cellular localizationCytoplasm.
  • Information by UniProt

Recombinant Human CARD14 protein images

  • Analysis of CARD14 Recombinant Protein, the purified protein shows a band at 50 kDa. Commassie blue stained gel.

References for Recombinant Human CARD14 protein (ab38230)

ab38230 has not yet been referenced specifically in any publications.

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