Overview

  • Product nameRecombinant Human CARD4 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ9Y239
    • SpeciesHuman
    • Molecular weight25 kDa
    • Amino acids710 to 936

Specifications

Our Abpromise guarantee covers the use of ab126000 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • ReconstitutionReconstitute with water to desired concentration.

General Info

  • Alternative names
    • CARD 4
    • CARD4
    • Caspase recruitment domain 4
    • Caspase recruitment domain containing protein 4
    • Caspase recruitment domain family member 4
    • Caspase recruitment domain protein 4
    • Caspase recruitment domain-containing protein 4
    • CLR 7.1
    • CLR7.1
    • NLR family CARD domain containing 1
    • NLRC 1
    • NLRC1
    • NOD 1
    • Nod1
    • NOD1 protein
    • NOD1_HUMAN
    • Nucleotide binding oligomerization domain containing 1
    • Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 1
    • Nucleotide-binding oligomerization domain-containing protein 1
    • Protein Nod1
    see all
  • FunctionEnhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.
  • Tissue specificityHighly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
  • Sequence similaritiesContains 1 CARD domain.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • Post-translational
    modifications
    Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF34 promotes proteasomal degradation and thereby negatively regulates NOD1 for instance in NF-kappa-B activition.
  • Cellular localizationCytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
  • Information by UniProt

References for Recombinant Human CARD4 protein (ab126000)

ab126000 has not yet been referenced specifically in any publications.

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