Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MRHHTRPIFLFLVETGFSHVGQAGLELLTSGDPPVSASQSAGIIGVSHRT WPCSSDFDAALGAGLELTLLPRLVVGTSLSPPEPRPAGPRGRVETCPSSS PGLGGHPCLHLL
    • Amino acids
      1 to 112
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Beta lyase
    • Beta lysase, kidney
    • CCBL 1
    • Cysteine conjugate beta lyase
    • Cysteine conjugate beta lyase, cytoplasmic
    • Cysteine conjugate beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)
    • Cysteine S conjugate beta lyase
    • Cytoplasmic cysteine conjugate beta lyase
    • FLJ95217
    • Glutamine phenylpyruvate aminotransferase
    • Glutamine transaminase K
    • GTK
    • KAT1
    • KATI
    • Kyneurenine aminotransferase
    • Kynurenine aminotransferase I
    • Kynurenine oxoglutarate transaminase 1
    • MGC29624
    • OTTHUMP00000022311
    • OTTHUMP00000022312
    see all
  • Relevance
    CCBL1 is a cytosolic enzyme which is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity. CCBL1 catalyzes the irreversible transamination of the L-tryptophan metabolite L-kinurenine to form kynurenic acid (KA). It catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. This enzyme has a central role in the bioactivation of nephrotoxic halogenated hydrocarbons - the possibility of human exposure to these chemicals has focused interest on the CCBL1 from human kidney.
  • Cellular localization
    Cytoplasmic

Images

  • ab158039 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158039 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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