The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
Additional notesThe biological activity of this product was determined by its ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/ml.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
C C motif chemokine ligand 21
C-C motif chemokine 21
Chemokine (C-C motif) ligand 21
Chemokine CC motif ligand 21
Efficient Chemoattractant for Lymphocytes
Secondary lymphoid-tissue chemokine
Small inducible cytokine A21
Small inducible cytokine subfamily A (Cys-Cys), member 21
Small-inducible cytokine A21
FunctionInhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.
Tissue specificityHighly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.