The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
< 1.000 Eu/µg
>95% by SDS-PAGE . Purity determined by SEC-HPLC and reducing SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term. Avoid freeze / thaw cycle.
pH: 7.40 Constituent: 100% PBS
Lyophilized from a 0.2 µM filtered solution
Reconstituted protein solution can be stored at 4°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
CCN family member 1
Cysteine rich angiogenic inducer 61
Cysteine rich heparin binding protein 61
Cysteine-rich angiogenic inducer 61
IGF-binding protein 10
Insulin like growth factor binding protein 10
Insulin-like growth factor-binding protein 10
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.