The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride
ReconstitutionReconstitute with water to desired concentration.
antigen CD11b (p170)
Antigen CD11b p170
CD11 antigen like family member B
CD11 antigen-like family member B
Cell surface glycoprotein MAC-1 subunit alpha
Complement component 3 receptor 3 subunit
Complement Component Receptor 3 Alpha
Complement receptor type 3, alpha subunit
CR 3 alpha chain
CR 3 alpha chain (CR3A)
CR-3 alpha chain
Integrin Alpha M
Integrin alpha M chain
Integrin beta 2 alpha subunit
Integrin subunit alpha M
integrin, alpha M (complement component 3 receptor 3 subunit)
Leukocyte adhesion receptor MO1
Mac1, alpha subunit
Macrophage antigen alpha polypeptide
Mo1, alpha subunit
Neutrophil adherence receptor
Neutrophil adherence receptor alpha M subunit
FunctionIntegrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Tissue specificityPredominantly expressed in monocytes and granulocytes.
Involvement in diseaseGenetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Sequence similaritiesBelongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain.
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.