The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ab168065 binds to Human CD134 (OX40). It activates T cell proliferation and delays neutrophil apoptosis.
< 0.100 Eu/µg
>95% by SDS-PAGE . ab168065 was purified by multi-step chromatography.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -80°C.
Constituent: 99% PBS
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute with 100µl sterile water for a final concentration of 0.1mg/ml. After reconstitution, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
glycoprotein 34 kd
OX40 antigen ligand
TAX transcriptionally-activated glycoprotein 1
Tumor necrosis factor (ligand) superfamily member 4
Tumor necrosis factor ligand superfamily member 4
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Involvement in disease
Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T cell-APC interaction and the functional consequences of T cell activation, thereby destabilizing peripheral tolerance.