The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Best use within three months from the date of receipt of this protein.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione
CD3 antigen, zeta polypeptide, isoform CRA_b
CD3 antigen, zeta subunit
CD3Z antigen zeta polypeptide (TiT3 complex)
T cell receptor T3 zeta chain
T cell surface glycoprotein CD3 zeta chain
T-cell antigen receptor complex, zeta subunit of CD3
T-cell receptor T3 zeta chain
T-cell surface glycoprotein CD3 zeta chain
TCR zeta chain
Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Involvement in disease
Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
Belongs to the CD3Z/FCER1G family. Contains 3 ITAM domains.
The ITAM domains mediate interaction with SHB.
Phosphorylated on Tyr residues after T-cell receptor triggering.